Silyl-protective groups influencing the reactivity and selectivity in glycosylations

Silyl groups such as TBDPS, TBDMS, TIPS or TMS are well-known and widely used alcohol protective groups in organic chemistry. Cyclic silylene protective groups are also becoming increasingly popular. In carbohydrate chemistry silyl protective groups have frequently been used primarily as an orthogonal protective group to the more commonly used acyl and benzyl protective groups. However, silyl protective groups have significantly different electronic and steric requirements than acyl and alkyl protective groups, which particularly becomes important when two or more neighboring alcohols are silyl protected. Within the last decade polysilylated glycosyl donors have been found to have unusual properties such as high (or low) reactivity or high stereoselectivity. This mini review will summarize these findings

DRIVER Technology Watch Report

This report is part of the Discovery Workpackage (WP4) and is the third report out of four deliverables. The objective of this report is to give an overview of the latest technical developments in the world of digital repositories, digital libraries and beyond, in order to serve as theoretical and practical input for the technical DRIVER developments, especially those focused on enhanced publications. This report consists of two main parts, one part focuses on interoperability standards for enhanced publications, the other part consists of three subchapters, which give a landscape picture of current and surfacing technologies and communities crucial to DRIVER. These three subchapters contain the GRID, CRIS and LTP communities and technologies. Every chapter contains a theoretical explanation, followed by case studies and the outcomes and opportunities for DRIVER in this field

Fedora Content Modelling for Improved Services for Research Databases

4th International Conference on Open RepositoriesThis presentation was part of the session : Fedora User Group PresentationsDate: 2009-05-21 08:30 AM – 10:00 AMA re-implementation of the research database of the Technical University of Denmark, DTU, is based on Fedora. The backbone consists of content models for primary and secondary entities and their relationships, giving flexible and powerful extraction capabilities for interoperability and reporting. By adopting such an abstract data model, the platform enables new and improved services for researchers, librarians and administrators

30.000 ways to reach 55% decarbonization of the European electricity sector

Climate change mitigation is a global challenge that, however, needs to be resolved by national-level authorities, resembling a tragedy of the commons. This paradox is reflected at European scale, as climate commitments are made by the EU collectively, but implementation is the responsibility of individual Member States. Here, we investigate 30.000 near-optimal effort-sharing scenarios where the European electricity sector is decarbonized by at least 55% relative to 1990, in line with 2030 ambitions. Using a highly detailed brownfield electricity system optimization model, the optimal electricity system is simulated for a suite of effort-sharing scenarios. Results reveal large inequalities in the efforts required to decarbonize national electricity sectors, with some countries facing cost-optimal pathways to reach 55% emission reductions, while others are confronted with relatively high abatement costs. Specifically, we find that several countries with modest or low levels of GDP per capita will experience high abatement costs, and when passed over into electricity prices this may lead to increased energy poverty in certain parts of Europ

DODEX – Geoscience Documents and Data for Exploration in Greenland

In the following we describe the project Geoscience Documents and Data for Exploration in Greenland, in short DODEX. A central part of DODEX is an interactive web application (http://www.geus.dk/dodex/) that provides easy access to all non-confidential company geoscience reports received by the authorities in Greenland and Denmark in accordance with the Mineral Resources Act of Greenland (1 January 2010) and associated regulations. From the web application it is possible to search in the DODEX report database using alphanumeric and geographic search criteria and to access report metadata. It is also possible to download the actual report as a PDF file. In addition to the open DODEX web application, the project also includes the development of a closed web application where authorised users can access confidential reports. The DODEX project was carried out at the Geological Survey of Denmark and Greenland (GEUS) in cooperation with the Bureau of Minerals and Petroleum (BMP) under the Government of Greenland as part of the promotion of the mineral resources of Greenland